Lupus Nephritis
Lupus Nephritis Is Among the Most Severe and Dangerous Complications of Systematic Lupus Erythematosus
Systematic lupus erythematosus (SLE), commonly known as lupus, is a chronic autoimmune disease where the body's immune system mistakenly attacks its own healthy tissues and organs. Over 200,000 people in the United States are estimated to have SLE, a of which 20% to 60% develop lupus nephritis (LN). b

a U.S. Centers for Disease Control and Prevention 2024
b KDIGO Lupus Nephritis Work Group, Kidney Int 2024
c Tamirou et al., Ann Rheum Dis 2016
Proteinuria Reduction Is Associated with Long-Term Renal Preservation
The larger the initial reduction in proteinuria in the first several months of management, the lower the risk of end-stage kidney disease.

a Adapted with permission from Chen et al., Clin J Am Soc Nephro 2008
b Retrospective analysis of patients (N=86) enrolled in the prospective, controlled study of plasmapheresis in severe LN to determine long-term prognosis of achieving partial response. Complete response was defined as SCr ≤1.4 mg/dL and proteinuria ≤0.33 g/day within 5 years of study entry, and partial response was defined as ≤25% increase in baseline SCr and ≥50% reduction in baseline proteinuria to ≤1.5 g/day (but >0.33 g/day) within 5 years of entering the study. Kidney survival was determined by kidney failure (≥6 mg/dL SCr or the initiation of kidney replacement therapy).
Even a Single Flare of LN Can Cause Irreversible Nephron Loss, Which Can Potentially Shorten the Lifespan of the Kidneys by Decades
Nephron loss and podocyte damage often lead to loss of kidney function as measured by glomerular filtration rate and proteinuria.

CKD=chronic kidney disease; GFR=glomerular filtration rate
aAdapted with permission from Anders et al., Nat Rev Dis Primers 2020